General Information:

Id: 2,002 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0004578 vascular smooth muscle cell
article
Reference: Zhang F et al.(2010) Different effects of angiotensin II and angiotensin-(1-7) on vascular smooth muscle cell proliferation and migration. PLoS ONE 5 [PMID: 20808802]

Interaction Information:

Comment Ang-(1-7) inhibits Ang II-induced SMC proliferation.
Formal Description
Interaction-ID: 15885

gene/protein

Angiotensin (1-7)

decreases_activity of

in vascular smooth muscle; if induced by angiotensin II, via MAS1
Comment Ang-(1-7) inhibits Ang II-induced SMC proliferation.
Formal Description
Interaction-ID: 15886

gene/protein

Angiotensin (1-7)

decreases_activity of

gene/protein

Angiotensin II

in vascular smooth muscle
Comment The AT1 receptor antagonist losartan blocked Ang II-induced SMC proliferation, whilst the MAS receptor antagonist A-779 abrogated the anti-proliferative effect of Ang-(1-7) on Ang II-induced SMC proliferation.
Formal Description
Interaction-ID: 15890

drug/chemical compound

A-779

decreases_activity of

gene/protein

Angiotensin (1-7)

Comment Ang II increased SMC migration, whereas Ang-(1-7) alone had no effect. However, cells treated with both Ang II and Ang-(1-7) had significant lower rate of migration compared with cells treated with Ang II alone, suggesting that Ang-(1-7) inhibited the stimulating effect of Ang II on SMC migration.
Formal Description
Interaction-ID: 15893

gene/protein

Angiotensin (1-7)

NOT increases_activity of

in vascular smooth muscle
Comment Ang II increased SMC migration, whereas Ang-(1-7) alone had no effect. However, cells treated with both Ang II and Ang-(1-7) had significant lower rate of migration compared with cells treated with Ang II alone, suggesting that Ang-(1-7) inhibited the stimulating effect of Ang II on SMC migration.
Formal Description
Interaction-ID: 15894

gene/protein

Angiotensin (1-7)

affects_activity of

in vascular smooth muscle; via inhibition of angiotensin II
Comment The ERK1/2 signaling pathway plays a major role in Ang II-induced SMC proliferation and migration. Ang II treatment stimulated phosphorylation of ERK1/2 and that this effect was significantly inhibited in the presence of Ang-(1-7).
Formal Description
Interaction-ID: 15898

gene/protein

Angiotensin (1-7)

affects_phosphorylation of

gene/protein

MAPK3/1

in vascular smooth muscle; via inhibition of angiotensin II