General Information:

Id: 1,988 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
isolated pancreatic islets
article
Reference: Lupi R et al.(2006) The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets. Eur. J. Endocrinol. 154: 355-361 [PMID: 16452552]

Interaction Information:

Comment Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression increased in islets cultured in high glucose; this was similarly prevented by the presence of either ACE inhibitor, zofenoprilat or enalaprilat.
Formal Description
Interaction-ID: 15620

drug/chemical compound

Enalaprilat

NOT increases_expression of

gene/protein

ACE

in pancreas, in pancreatic islets; after glucose stimulation
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