General Information:

Id: 1,987 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
primary cultured human preadipocytes
Reference: Janke J et al.(2002) Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors. Diabetes 51: 1699-1707 [PMID: 12031955]

Interaction Information:

Comment Adipogenesis was accompanied by increased RNA expression of the early marker gene PPAR-gamma and the intermediate marker gene for leptin. Adipogenic differentiation was also associated with a marked increase in the RNA expression of AGT, REN, ACE, and AT1. In contrast, AT2 RNA expression was barely detectable in preadipocytes and increased only marginally during adipogenesis.
Formal Description
Interaction-ID: 15594

increases_expression of



in adipose tissue
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