General Information:

Id: 1,976 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
leptin receptor-deficient db/db mouse and control (db/m) mouse infected with an adenovirus expressing human ACE2 (Ad-hACE2-eGFP) or the control virus (Ad-eGFP) via injection into the pancreas
article
Reference: Bindom SM et al.(2010) Angiotensin I-converting enzyme type 2 (ACE2) gene therapy improves glycemic control in diabetic mice. Diabetes 59: 2540-2548 [PMID: 20660625]

Interaction Information:

Comment Ad-eGFP treatment had no effect on db/db or db/m fasting blood glucose levels or glucose tolerance at 4, 8, or 16 weeks. On the other hand, ACE2 overexpression significantly decreased fasting blood glucose in diabetic mice at both 8 and 16 weeks of age.
Formal Description
Interaction-ID: 15479

gene/protein

ACE2

decreases_quantity of

drug/chemical compound

Glucose

in blood; after fasting
Drugbank entries Show/Hide entries for ACE2