General Information:

Id: 1,953
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse
article/cited
Reference: Chiba T et al.(2009) Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Mol. Psychiatry 14: 206-222 [PMID: 18813209]

Interaction Information:

Comment Humanin (HN) is a short neuroprotective peptide abolishing Abeta neurotoxicity.
Formal Description
Interaction-ID: 15126

drug/chemical compound

Humanin

affects_activity of

gene/protein

Amyloid beta peptide

Comment Humanin (HN) is a short neuroprotective peptide abolishing Abeta neurotoxicity.
Formal Description
Interaction-ID: 15127

drug/chemical compound

Humanin

decreases_activity of

process

neuron death

via Abeta neurotoxicity
Comment Intracranial soluble amyloid-beta (Abeta) levels has been implicated in the pathogenesis of Alzheimer's disease (AD). (cited information)
Formal Description
Interaction-ID: 15128

complex/PPI

Amyloid beta peptide (soluble)

affects_activity of

Comment HN derivatives activate the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling axis.
Formal Description
Interaction-ID: 15130

drug/chemical compound

Humanin derivative

increases_activity of

gene/protein

JAK2

Drugbank entries Show/Hide entries for JAK2
Comment HN derivatives activate the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling axis.
Formal Description
Interaction-ID: 15131

drug/chemical compound

Humanin derivative

increases_activity of

gene/protein

STAT3

Comment HN derivative named colivelin completely restored cognitive function in an AD model (Tg2576) by activating the JAK2/STAT3 axis.
Formal Description
Interaction-ID: 15132

drug/chemical compound

Colivelin

decreases_activity of

phenotype

cognitive impairment

Comment HN derivative named colivelin completely restored cognitive function in an AD model (Tg2576) by activating the JAK2/STAT3 axis.
Formal Description
Interaction-ID: 15136

drug/chemical compound

Colivelin

increases_activity of

(JAK2/STAT3 axis)
Comment p-STAT3 levels in hippocampal neurons age-dependently decreased in both AD model mice and AD patients.
Formal Description
Interaction-ID: 15137

process

aging

decreases_quantity of

protein modification

STAT3-phos

in hippocampal neurons in AD mouse model and AD patients
Comment Intracerebroventricular administration of Abeta1-42 downregulated p-STAT3.
Formal Description
Interaction-ID: 15138

decreases_quantity of

protein modification

STAT3-phos

Comment Hypothesis: Abeta-dependent inactivation of the JAK2/STAT3 axis causes memory loss through cholinergic dysfunction.
Formal Description
Interaction-ID: 15139

none selected

Drugbank entries Show/Hide entries for or
Comment HN derivative named colivelin completely restored cognitive function in an AD model (Tg2576) by activating the JAK2/STAT3 axis.
Formal Description
Interaction-ID: 19175

drug/chemical compound

Colivelin

decreases_activity of

phenotype

cognitive impairment