General Information:

Id: 1,893 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Vance JE and Hayashi H(2010) Formation and function of apolipoprotein E-containing lipoproteins in the nervous system Biochim. Biophys. Acta 1801: 806-818 [PMID: 20170744]

Interaction Information:

Comment Individuals with one APOE4 isoform are 3 to 4 times as likely to develop AD as those without any APOE4, and people with two APOE4 alleles have a 12-fold higher risk of developing AD.
Formal Description
Interaction-ID: 14500

gene/protein mutant

APOE (isoform E4)

increases_activity of