General Information:

Id: 1,592 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000195 CACO-2 cell
Reference: Sergent T et al.(2010) Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium Chem Biol Interact 188: 659-667 [PMID: 20816778]

Interaction Information:

Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11595

drug/chemical compound


decreases_expression of



in inflamed cells
Drugbank entries Show/Hide entries for Genistein or TGFB1
Comment CD14, IFNGR1, NOD2, TLR4, CCL2, CCL5, HLA-DRA, ICAM1, IL1A, IL1B, IL6, IL8, IL15, NOS2A, PLA2G2A, IL1R1, TNFRSF1A, PTGS1, TGFB1, NFKBIA, and TNF are involved in inflammation.
Formal Description
Interaction-ID: 11633



affects_activity of

Drugbank entries Show/Hide entries for TGFB1