General Information:

Id: 1,559
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
transgenic ob/ob mouse overexpressing adiponectin
article
Reference: Kim JY et al.(2007) Obesity-associated improvements in metabolic profile through expansion of adipose tissue J. Clin. Invest. 117: 2621-2637 [PMID: 17717599]

Interaction Information:

Comment Modest overexpression of adiponectin in ob/ob mice improved fasting glucose, insulin, triglyceride and free fatty acid (FFA) levels, metabolic parameters that are dysregulated in ob/ob mice.
Formal Description
Interaction-ID: 11126

gene/protein

ADIPOQ

affects_quantity of

drug/chemical compound

Glucose

in blood; after fasting
Comment Modest overexpression of adiponectin in ob/ob mice improved fasting glucose, insulin, triglyceride and free fatty acid (FFA) levels, metabolic parameters that are dysregulated in ob/ob mice.
Formal Description
Interaction-ID: 11140

gene/protein

ADIPOQ

affects_quantity of

complex/PPI

Insulin

in blood
Comment Modest overexpression of adiponectin in ob/ob mice improved fasting glucose, insulin, triglyceride and free fatty acid (FFA) levels, metabolic parameters that are dysregulated in ob/ob mice.
Formal Description
Interaction-ID: 11143

gene/protein

ADIPOQ

affects_quantity of

drug/chemical compound

Triacylglycerol

in blood
Comment Modest overexpression of adiponectin in ob/ob mice improved fasting glucose, insulin, triglyceride and free fatty acid (FFA) levels, metabolic parameters that are dysregulated in ob/ob mice.
Formal Description
Interaction-ID: 11144

gene/protein

ADIPOQ

affects_quantity of

drug/chemical compound

Fatty acid

in blood
Comment High-fat diet further impaired the metabolic state of ob/ob mice, yet adiponectin-overexpressing ob/ob mice are resistant to this high-fat diet-induced deterioration of metabolic parameters.
Formal Description
Interaction-ID: 11169

gene/protein

ADIPOQ

affects_activity of

environment

high-fat diet

in ob/ob mice
Comment The transgenic adiponectin-overexpressing ob/ob mice were morbidly obese, with significantly higher levels of adipose tissue than their ob/ob littermates, leading to an interesting dichotomy of increased fat mass associated with improvement in insulin sensitivity.
Formal Description
Interaction-ID: 11170

gene/protein

ADIPOQ

affects_activity of

disease

Obesity

Comment Measurements of total liver triglycerides showed a marked decrease of hepatic steatosis and DAG levels in ob/ob mice overexpressing adiponectin.
Formal Description
Interaction-ID: 11171

gene/protein

ADIPOQ

decreases_activity of

disease

Fatty liver disease, nonalcoholic

in liver
Comment Measurements of total liver triglycerides showed a marked decrease of hepatic steatosis and DAG levels in ob/ob mice overexpressing adiponectin.
Formal Description
Interaction-ID: 11173

gene/protein

ADIPOQ

decreases_activity of

drug/chemical compound

Diacylglycerol

in liver
Comment Subcutaneous, but not intraabdominal, fat pads increased in size in adiponectin-overexpressing ob/ob mice.
Formal Description
Interaction-ID: 11175

gene/protein

ADIPOQ

increases_quantity of

tissue/cell line

subcutaneous adipose tissue

Comment Adiponectin-overexpressing ob/ob mice showed significant improvements in hepatic insulin sensitivity.
Formal Description
Interaction-ID: 11176

gene/protein

ADIPOQ

affects_activity of

in liver
Comment Excess adiponectin normalizes pancreatic islet histology and improves both local and systemic inflammation: the circulating IL-6 levels and the TNF-alpha level in adipose tissue were reduced.
Formal Description
Interaction-ID: 11177

gene/protein

ADIPOQ

affects_activity of

Comment Excess adiponectin normalizes pancreatic islet histology and improves both local and systemic inflammation: the circulating IL-6 levels and the TNF-alpha level in adipose tissue were reduced.
Formal Description
Interaction-ID: 11178

gene/protein

ADIPOQ

affects_quantity of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment Excess adiponectin normalizes pancreatic islet histology and improves both local and systemic inflammation: the circulating IL-6 levels and the TNF-alpha level in adipose tissue were reduced.
Formal Description
Interaction-ID: 11179

gene/protein

ADIPOQ

affects_quantity of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment Lipoprotein lipase (LPL), which plays a key role in the clearance of circulating triglycerides and their routing towards storage or oxidative tissues, showed increased activity in several white fat pads and plasma of adiponectin-overexpressing transgenic ob/ob mice.
Formal Description
Interaction-ID: 11180

gene/protein

ADIPOQ

affects_activity of

gene/protein

LPL

in white adipose tissue, in blood
Drugbank entries Show/Hide entries for LPL
Comment The mRNA levels of cytosolic phosphoenolpyruvate carboxykinase (PEPCK), diacylglycerol acyltransferase (DGAT-1), PPAR-gamma-2, and adipocyte/macrophage fatty-acid-binding protein (aP2), all of them well established PPAR-gamma targets, were increased in adipose tissue of ob/ob mice overexpressing adiponectin.
Formal Description
Interaction-ID: 11183

gene/protein

ADIPOQ

affects_expression of

gene/protein

PCK1

in white adipose tissue
Drugbank entries Show/Hide entries for PCK1
Comment The mRNA levels of cytosolic phosphoenolpyruvate carboxykinase (PEPCK), diacylglycerol acyltransferase (DGAT-1), PPAR-gamma-2, and adipocyte/macrophage fatty-acid-binding protein (aP2), all of them well established PPAR-gamma targets, were increased in adipose tissue of ob/ob mice overexpressing adiponectin.
Formal Description
Interaction-ID: 11190

gene/protein

ADIPOQ

affects_expression of

gene/protein

DGAT1

in white adipose tissue
Comment The mRNA levels of cytosolic phosphoenolpyruvate carboxykinase (PEPCK), diacylglycerol acyltransferase (DGAT-1), PPAR-gamma-2, and adipocyte/macrophage fatty-acid-binding protein (aP2), all of them well established PPAR-gamma targets, were increased in adipose tissue of ob/ob mice overexpressing adiponectin.
Formal Description
Interaction-ID: 11191

gene/protein

ADIPOQ

affects_expression of

mRNA/protein variant

PPARG2

in white adipose tissue
Comment The mRNA levels of cytosolic phosphoenolpyruvate carboxykinase (PEPCK), diacylglycerol acyltransferase (DGAT-1), PPAR-gamma-2, and adipocyte/macrophage fatty-acid-binding protein (aP2), all of them well established PPAR-gamma targets, were increased in adipose tissue of ob/ob mice overexpressing adiponectin.
Formal Description
Interaction-ID: 11193

gene/protein

ADIPOQ

affects_expression of

gene/protein

FABP4

in white adipose tissue
Comment The mRNA levels of cytosolic phosphoenolpyruvate carboxykinase (PEPCK), diacylglycerol acyltransferase (DGAT-1), PPAR-gamma-2, and adipocyte/macrophage fatty-acid-binding protein (aP2), all of them well established PPAR-gamma targets, were increased in adipose tissue of ob/ob mice overexpressing adiponectin.
Formal Description
Interaction-ID: 11194

gene/protein

ADIPOQ

affects_activity of

gene/protein

PPARG

in white adipose tissue
Drugbank entries Show/Hide entries for PPARG
Comment In transgenic ob/ob mice overespressing adiponectin the mRNA levels of PPAR-gamma, PGC1-alpha,beta, and RXR-alpha were increased in adipose tissue.
Formal Description
Interaction-ID: 11195

gene/protein

ADIPOQ

increases_expression of

gene/protein

PPARG

in adipose tissue
Drugbank entries Show/Hide entries for PPARG
Comment In transgenic ob/ob mice overespressing adiponectin the mRNA levels of PPAR-gamma, PGC1-alpha,beta, and RXR-alpha were increased in adipose tissue.
Formal Description
Interaction-ID: 11196

gene/protein

ADIPOQ

increases_expression of

gene/protein

PPARGC1A

in adipose tissue
Comment In transgenic ob/ob mice overespressing adiponectin the mRNA levels of PPAR-gamma, PGC1-alpha,beta, and RXR-alpha were increased in adipose tissue.
Formal Description
Interaction-ID: 11197

gene/protein

ADIPOQ

increases_expression of

gene/protein

PPARGC1B

in adipose tissue
Comment In transgenic ob/ob mice overespressing adiponectin the mRNA levels of PPAR-gamma, PGC1-alpha,beta, and RXR-alpha were increased in adipose tissue.
Formal Description
Interaction-ID: 11198

gene/protein

ADIPOQ

increases_expression of

gene/protein

RXRA

in adipose tissue
Drugbank entries Show/Hide entries for RXRA
Comment Elevation of peripheral adiponectin reduces food intake and energy expenditure.
Formal Description
Interaction-ID: 11199

gene/protein

ADIPOQ

decreases_activity of

Comment Increasing adiponectin levels in the absence of leptin leads to starvation intolerance.
Formal Description
Interaction-ID: 11200

gene/protein

ADIPOQ

affects_activity of

if leptin is absent
Comment Elevation of peripheral adiponectin reduces food intake and energy expenditure.
Formal Description
Interaction-ID: 13579

gene/protein

ADIPOQ

decreases_activity of

Comment Subcutaneous, but not intraabdominal, fat pads increased in size in adiponectin-overexpressing ob/ob mice.
Formal Description
Interaction-ID: 46085

gene/protein

ADIPOQ

NOT increases_quantity of

tissue/cell line

abdominal adipose tissue