General Information:

Id: 1,534 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Nikolaev A et al.(2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989 [PMID: 19225519]

Interaction Information:

Comment APP and DR6 are components of a neuronal self-destruction pathway and contribute to Alzheimer's disease.
Formal Description
Interaction-ID: 10956

gene/protein

APP

affects_activity of

Drugbank entries Show/Hide entries for APP
Comment APP binds DR6 to trigger axon pruning and neuron death via distinct caspases e.g. caspase-6.
Formal Description
Interaction-ID: 10957

gene/protein

APP

interacts (colocalizes) with

gene/protein

TNFRSF21

compare Corum:6056
Drugbank entries Show/Hide entries for APP