General Information:

Id: 1,530 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Chakrabarti SK et al.(2009) 12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes Obesity (Silver Spring) 17: 1657-1663 [PMID: 19521344]

Interaction Information:

Comment The saturated fatty acid palmitate, a major component of high fat diets, augmented expression of 12/15-LO in 3T3-L1 adipocytes. Both TNF-alpha and IL-6 expression were upregulated whereas adiponectin expression was reduced by palmitic acid.
Formal Description
Interaction-ID: 10947

drug/chemical compound

Palmitic acid

decreases_expression of



in adipose tissue
Drugbank entries Show/Hide entries for Palmitic acid