General Information:

Id: 1,530 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Chakrabarti SK et al.(2009) 12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes Obesity (Silver Spring) 17: 1657-1663 [PMID: 19521344]

Interaction Information:

Comment When 3T3-L1 adipocytes were treated with the 12/15-LO products, 12-hydroxyeicosatetranoic acid (12(S)-HETE) and 12-hydroperoxyeicosatetraenoic acid (12(S)-HPETE), expression of proinflammatory cytokine genes, including tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), and IL-12p40, was upregulated whereas anti-inflammatory adiponectin gene expression was downregulated.
Formal Description
Interaction-ID: 10933

drug/chemical compound

12(S)-HETE

decreases_expression of

gene/protein

ADIPOQ

in adipose tissue
Comment When 3T3-L1 adipocytes were treated with the 12/15-LO products, 12-hydroxyeicosatetranoic acid (12(S)-HETE) and 12-hydroperoxyeicosatetraenoic acid (12(S)-HPETE), expression of proinflammatory cytokine genes, including tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), and IL-12p40, was upregulated whereas anti-inflammatory adiponectin gene expression was downregulated.
Formal Description
Interaction-ID: 10938

drug/chemical compound

12(S)-HPETE

decreases_expression of

gene/protein

ADIPOQ

in adipose tissue
Comment The saturated fatty acid palmitate, a major component of high fat diets, augmented expression of 12/15-LO in 3T3-L1 adipocytes. Both TNF-alpha and IL-6 expression were upregulated whereas adiponectin expression was reduced by palmitic acid.
Formal Description
Interaction-ID: 10947

drug/chemical compound

Palmitic acid

decreases_expression of

gene/protein

ADIPOQ

in adipose tissue
Drugbank entries Show/Hide entries for Palmitic acid