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Field	Query

	Field	Term

General Information:

Id:	15,007
Diseases:	Ciliopathy
Organism:	Homo sapiens
Publication type:	article
Reference:	[PMID: 24421332]

Interaction Information:

Comment	Talpid3 was coimmunoprecipitated with CP110 and Kif24 antibodies. Reciprocal immunoprecipitations with a Talpid3 antibody confirmed its interaction with CP110, Cep97, and Kif24, and, to a lesser extent, with Cep290. Talpid3 robustly binds to CP110 and more weakly associ- ates with Cep97, Cep290, and Kif24.
Formal Description Interaction-ID: 140591	gene/protein KIAA0586 interacts (colocalizes) with gene/protein CCP110

Comment	Talpid3 was coimmunoprecipitated with CP110 and Kif24 antibodies. Reciprocal immunoprecipitations with a Talpid3 antibody confirmed its interaction with CP110, Cep97, and Kif24, and, to a lesser extent, with Cep290. Talpid3 robustly binds to CP110 and more weakly associ- ates with Cep97, Cep290, and Kif24.
Formal Description Interaction-ID: 140592	gene/protein KIAA0586 interacts (colocalizes) with gene/protein CEP97

Comment	Talpid3 was coimmunoprecipitated with CP110 and Kif24 antibodies. Reciprocal immunoprecipitations with a Talpid3 antibody confirmed its interaction with CP110, Cep97, and Kif24, and, to a lesser extent, with Cep290. Talpid3 robustly binds to CP110 and more weakly associ- ates with Cep97, Cep290, and Kif24.
Formal Description Interaction-ID: 140593	gene/protein KIAA0586 interacts (colocalizes) with gene/protein CEP290

Comment	Talpid3 was coimmunoprecipitated with CP110 and Kif24 antibodies. Reciprocal immunoprecipitations with a Talpid3 antibody confirmed its interaction with CP110, Cep97, and Kif24, and, to a lesser extent, with Cep290. Talpid3 robustly binds to CP110 and more weakly associ- ates with Cep97, Cep290, and Kif24.
Formal Description Interaction-ID: 140594	gene/protein KIAA0586 interacts (colocalizes) with gene/protein KIF24

Comment	Talpid3 localizes to the distal ends of centrioles, close to other components of CP110-containing protein complexes and near the distal appendages.
Formal Description Interaction-ID: 140595	gene/protein KIAA0586 is localized in cellular component centriole

Comment	Depletion of Talpid3 prevents primary cilia formation.
Formal Description Interaction-ID: 140596	gene/protein KIAA0586 affects_activity of process cilium assembly

Comment	PCM1 was identified as an interacting protein, suggesting that Talpid3, like Cep290, associates with this component of centriolar satellites.
Formal Description Interaction-ID: 140597	gene/protein KIAA0586 interacts (colocalizes) with gene/protein PCM1 in RPE1 cells

Comment	The authors performed immunoprecipitations using RPE1 cell lysates and observed that PCM1 interacts with Talpid3, CP110, and Cep97 as well as Cep290.
Formal Description Interaction-ID: 140598	gene/protein PCM1 interacts (colocalizes) with gene/protein CCP110 in RPE1 cells

Comment	The authors performed immunoprecipitations using RPE1 cell lysates and observed that PCM1 interacts with Talpid3, CP110, and Cep97 as well as Cep290.
Formal Description Interaction-ID: 140599	gene/protein PCM1 interacts (colocalizes) with gene/protein CEP97 in RPE1 cells

Comment	The authors performed immunoprecipitations using RPE1 cell lysates and observed that PCM1 interacts with Talpid3, CP110, and Cep97 as well as Cep290.
Formal Description Interaction-ID: 140600	gene/protein PCM1 interacts (colocalizes) with gene/protein CEP290 in RPE1 cells

Comment	Talpid3 and Cep290 are required for proper localization of Rab8a.
Formal Description Interaction-ID: 140601	gene/protein KIAA0586 affects_activity of gene/protein RAB8A

Comment	Talpid3 and Cep290 are required for proper localization of Rab8a.
Formal Description Interaction-ID: 140602	gene/protein CEP290 affects_activity of gene/protein RAB8A

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