General Information:

Id: 1,441 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Hemochromatosis, type 1 - [OMIM]
Mammalia
review
Reference: Cahill CM et al.(2009) Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases Biochim. Biophys. Acta 1790: 615-628 [PMID: 19166904]

Interaction Information:

Comment There are evidences of metal dependent translation of APP mRNA, the involvement of metals in the plaque of AD patients and of increased iron in striatal neurons in the substantia nigra (SN) of Parkinson's disease patients.
Formal Description
Interaction-ID: 10118

drug/chemical compound

Metal

affects_expression of

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment Iron enhances cleavage of the Abeta-peptide domain of APP by the metalloprotease alpha secretase.
Formal Description
Interaction-ID: 10385

gene/protein

Alpha-secretase

increases_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment APP transcription is up-regulated by copper.
Formal Description
Interaction-ID: 10386

drug/chemical compound

Copper

increases_expression of

gene/protein

APP

Up-regulation of APP transcription
Drugbank entries Show/Hide entries for APP