General Information:

Id: 142 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
Reference: Muqit MM et al.(2006) Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J. Neurochem. 98: 156-169 [PMID: 16805805]

Interaction Information:

Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 510



is localized in

cellular component


if PARK2 is overexpressed