General Information:

Id: 1,422 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
review
Reference: Rogers JT et al.(2008) Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimers disease Biochem. Soc. Trans. 36: 1282-1287 [PMID: 19021541]

Interaction Information:

Comment APP was regulated at the translational level by active IL (interleukin)-1 (IL-1-responsive acute box) and IRE (iron-responsive element) RNA stem-loops in the 5' untranslated region of APP mRNA.
Formal Description
Interaction-ID: 9878

gene/protein

IL1B (active form)

affects_expression of

gene/protein

APP

at translational level
Drugbank entries Show/Hide entries for APP
Comment Secreted APP can act as an anti-coagulant by binding to Factor IXa, leading to the production of fibrinogen from fibrin.
Formal Description
Interaction-ID: 9960

gene/protein

APP

affects_activity of

process

coagulation

If APP is secreted
Drugbank entries Show/Hide entries for APP
Comment Secreted APP can act as an anti-coagulant by binding to factor IXa, leading to the production of fibrinogen from fibrin.
Formal Description
Interaction-ID: 9963

gene/protein

APP

interacts (colocalizes) with

gene/protein

Factor IXa

If APP is secreted
Drugbank entries Show/Hide entries for APP
Comment APP is increased after IL (interleukin)-1-mediated stress responses by translational up-regulation of APP mRNA translation at the same time by as induction of alpha-secretase activity to generate the 90 kDa APP(s) (alpha-secretase cleavage in the APP Abeta domain).
Formal Description
Interaction-ID: 9967

increases_expression of

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment APP provides protection against catalysed oxidative stress.
Formal Description
Interaction-ID: 9976

gene/protein

APP

decreases_activity of

Drugbank entries Show/Hide entries for APP
Comment APP provides protection against catalysed oxidative stress.
Formal Description
Interaction-ID: 9979

gene/protein

APP

increases_activity of

Drugbank entries Show/Hide entries for APP
Comment Primary inflammatory cytokine induces the non-amyloidogenic secretion of APP(s) from astrocytes.
Formal Description
Interaction-ID: 10036

increases_quantity of

gene/protein

APP

Drugbank entries Show/Hide entries for APP