General Information:

Id: 142
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Muqit MM et al.(2006) Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J. Neurochem. 98: 156-169 [PMID: 16805805]

Interaction Information:

Comment PINK1 and mutant PINK1-G309D localize both to the mitochondrial inner membrane.
Formal Description
Interaction-ID: 506

gene/protein

PINK1

is localized in

cellular component

mitochondrial inner membrane

Comment PINK1 and mutant PINK1-G309D localize both to the mitochondrial inner membrane.
Formal Description
Interaction-ID: 507

gene/protein mutant

PINK1-p.G309D

is localized in

cellular component

mitochondrial inner membrane

Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 508

gene/protein

PINK1

is localized in

cellular component

aggresome

after proteasome inhibition with MG-132
Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 509

gene/protein

SNCAIP

is localized in

cellular component

aggresome

if SNCAIP is overexpressed
Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 510

gene/protein

PRKN

is localized in

cellular component

aggresome

if PARK2 is overexpressed
Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 511

gene/protein

SNCA

is localized in

cellular component

aggresome

if SNCA is overexpressed
Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 512

gene/protein

UCHL1

is localized in

cellular component

aggresome

if UCHL1 is overexpressed
Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 514

gene/protein

VIM

is localized in

cellular component

aggresome

Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 515

gene/protein

RPS27A

is localized in

cellular component

aggresome

Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 516

gene/protein

HSPA8

is localized in

cellular component

aggresome

Drugbank entries Show/Hide entries for HSPA8
Comment PINK1 co-localizes with PD-associated proteins, like synphilin-1, parkin, alpha-synuclein, UCH-L1 and known aggresome proteins, like vimentin, ubiquitin and Hsc-70, in aggresomes after proteasome inhibition with MG-132 for 24 hours. DJ-1 does not localize to aggresomes after proteasome inhibition.
Formal Description
Interaction-ID: 518

gene/protein

PARK7

NOT is localized in

cellular component

aggresome

after proteasome inhibition with MG-132
Drugbank entries Show/Hide entries for PARK7
Comment PINK1 is localized in Lewy Bodies.
Formal Description
Interaction-ID: 520

gene/protein

PINK1

is localized in