General Information:

Id: 1,418 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cell
article
Reference: Duce JA et al.(2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimers disease Cell 142: 857-867 [PMID: 20817278]

Interaction Information:

Comment Cortical APP ferroxidase activity is decreased in Alzheimer's disease. APP ferroxidase activity is not changed in cortical tissue from non-beta-amyloid burdened neurodegenerative diseases such as Frontotemporal dementia and Parkinson’s disease.
Formal Description
Interaction-ID: 9875

decreases_activity of

gene/protein

APP

cortical APP ferroxidase activity
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