General Information:

Id: 1,418 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cell
article
Reference: Duce JA et al.(2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimers disease Cell 142: 857-867 [PMID: 20817278]

Interaction Information:

Comment APP catalytically oxidizes Fe2+, loads Fe3+ into transferrin, and has a major interaction with ferroportin in HEK293T cells (that lack ceruloplasmin) and in human cortical tissue.
Formal Description
Interaction-ID: 9807

gene/protein

APP

increases_activity of

Fe3+ binding; APP loads Fe3+ into transferrin
Drugbank entries Show/Hide entries for APP