General Information:

Id: 1,321 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000567 HeLa cell
article
Reference: Wang R et al.(2006) Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia FASEB J. 20: 1275-1277 [PMID: 16645044]

Interaction Information:

Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1A.
Formal Description
Interaction-ID: 9036

complex/PPI

Gamma-secretase complex

increases_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for APP