General Information:

Id: 1,321
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000567 HeLa cell
article
Reference: Wang R et al.(2006) Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia FASEB J. 20: 1275-1277 [PMID: 16645044]

Interaction Information:

Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1.
Formal Description
Interaction-ID: 9031

affects_activity of

gene/protein

HIF1A

Drugbank entries Show/Hide entries for HIF1A
Comment Transcription factor AP4 and HIF-1A play a significant role in regulating APH-1A gene expression.
Formal Description
Interaction-ID: 9032

gene/protein

TFAP4

affects_expression of

gene/protein

APH1A

Comment Transcription factor AP4 and HIF-1A play a significant role in regulating APH-1A gene expression.
Formal Description
Interaction-ID: 9033

gene/protein

HIF1A

affects_expression of

gene/protein

APH1A

HIF-1 activated by hypoxia
Drugbank entries Show/Hide entries for HIF1A
Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1A.
Formal Description
Interaction-ID: 9034

gene/protein

HIF1A

affects_quantity of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for HIF1A
Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1A.
Formal Description
Interaction-ID: 9035

gene/protein

HIF1A

affects_activity of

complex/PPI

Gamma-secretase complex

Drugbank entries Show/Hide entries for HIF1A
Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1A.
Formal Description
Interaction-ID: 9036

complex/PPI

Gamma-secretase complex

increases_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1A.
Formal Description
Interaction-ID: 9037

complex/PPI

Gamma-secretase complex

increases_processing of

gene/protein

NOTCH

Comment Nickel treatment (a condition of chemical hypoxia) or hypoxia increases HIF-1alpha concentration, which binds to HIF-1beta to form activated HIF-1 heterodimers. Activated HIF-1 promotes the transcription and translation of APH-1A. Increased APH-1A concentration probably promotes the gamma-secretase activity, hence enhances the processing of APP to generate Abeta and the cleavage of Notch to release NICD.
Formal Description
Interaction-ID: 24457

drug/chemical compound

Nickel

increases_quantity of

gene/protein

HIF1A

Drugbank entries Show/Hide entries for HIF1A
Comment Nickel treatment (a condition of chemical hypoxia) or hypoxia increases HIF-1alpha concentration, which binds to HIF-1beta to form activated HIF-1 heterodimers. Activated HIF-1 promotes the transcription and translation of APH-1A. Increased APH-1A concentration probably promotes the gamma-secretase activity, hence enhances the processing of APP to generate Abeta and the cleavage of Notch to release NICD.
Formal Description
Interaction-ID: 24458

gene/protein

HIF1A

interacts (colocalizes) with

gene/protein

ARNT

Drugbank entries Show/Hide entries for HIF1A
Comment Nickel treatment (a condition of chemical hypoxia) or hypoxia increases HIF-1alpha concentration, which binds to HIF-1beta to form activated HIF-1 heterodimers. Activated HIF-1 promotes the transcription and translation of APH-1A. Increased APH-1A concentration probably promotes the gamma-secretase activity, hence enhances the processing of APP to generate Abeta and the cleavage of Notch to release NICD.
Formal Description
Interaction-ID: 24459

gene/protein

HIF1A

is_part_of

complex/PPI

ARNT-HIF1A complex

Drugbank entries Show/Hide entries for HIF1A
Comment Nickel treatment (a condition of chemical hypoxia) or hypoxia increases HIF-1alpha concentration, which binds to HIF-1beta to form activated HIF-1 heterodimers. Activated HIF-1 promotes the transcription and translation of APH-1A. Increased APH-1A concentration probably promotes the gamma-secretase activity, hence enhances the processing of APP to generate Abeta and the cleavage of Notch to release NICD.
Formal Description
Interaction-ID: 24460

gene/protein

ARNT

is_part_of

complex/PPI

ARNT-HIF1A complex

Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1A.
Formal Description
Interaction-ID: 81263

complex/PPI

Gamma-secretase complex

increases_quantity of

gene/protein

NOTCH (intracellular domain NICD)

Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1A.
Formal Description
Interaction-ID: 81264

complex/PPI

Gamma-secretase complex

increases_quantity of

gene/protein

Amyloid beta peptide

Comment APH-1A expression and the gamma-secretase mediated Abeta and Notch NICD generation are regulated by hypoxia/HIF-1A.
Formal Description
Interaction-ID: 81265

complex/PPI

Gamma-secretase complex

affects_activity of