General Information:

Id: 1,267 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
Reference: Kang K et al.(2008) Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity Cell Metab. 6: 485-495 [PMID: 18522830]

Interaction Information:

Comment PPARD-/- white adipose tissue showed the presence of many small adipocytes surrounded by macrophages. Examination of relevant metabolic genes revealed that the expression of the genes encoding GLUT4 and perilipin, a lipid droplet-coating protein controlling lipid storage and lipolysis, was downregulated, whereas genes encoding lipogenesis (fatty acid synthase [Fas]), fatty acid oxidation (carnitine palmitoyltransferase 1 [Cpt1]), and adipokines (leptin and adiponectin) were unaffected.
Formal Description
Interaction-ID: 8643



NOT affects_expression of



in white adipose tissue
Drugbank entries Show/Hide entries for PPARD