General Information:

Id: 1,232 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
Reference: Mamane Y et al.(2009) The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation Diabetes 58: 2006-2017 [PMID: 19581423]

Interaction Information:

Comment MCP-1 and IL-6 are adipokines believed to initiate macrophage infiltration in the WAT and involved in systemic insulin resistance. Indeed, a significant increase in MCP-1 mRNA levels was seen in wild-type mice on HFD compared with ND (fourfold). MCP-1 expression in C3aR-/- mice on HFD was 1.7-fold lower than wild-type controls. A definitive trend toward decreased IL-6 expression was seen in both the C3aR-/- and C3aR-/- mice on HFD compared with wild type.
Formal Description
Interaction-ID: 8372



affects_expression of



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