Artegiani B et al.(2015) Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis EMBO J. 34: 896-910
[PMID: 25527292]
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The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
The authors sought to manually inspect individual Tox peaks for at least some of the genes that are known to play key roles in CNS development including proliferation versus differentiation of neural progenitors and maturation and specification of postmitotic neurons. These
included: (i) key members of the Shh, Wnt, Notch and Fgf signalling pathways (Gli1); (ii) well-characterized regulators of neural stem cell fate such as Tbr2/Eomes, Sox2, Prox1, Foxp1/2 and Yap1; and (iii) genes involved in neuronal maturation and specification such as Robo2, Tbr1, Satb2 and Erbb4.
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