General Information:

Id: 1,217 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Riant E et al.(2009) Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice Endocrinology 150: 2109-2117 [PMID: 19164473]

Interaction Information:

Comment During the short-term high-fat feeding period, E2 treatment significantly increased the level of IL-6, TNF-alpha, and PAI-1 mRNAs in both the liver and visceral adipose tissue, compared with results obtained in placebo-treated ovariectomized mice.
Formal Description
Interaction-ID: 8204

drug/chemical compound


increases_expression of



in liver, in visceral adipose tissue; after 1 month of high-fat feeding
Drugbank entries Show/Hide entries for Estradiol or IL6