General Information:

Id: 12,009 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Mus musculus
Reference: Pan X et al.(2018) FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice Cell Metab. 27: 1323-1337.e5 [PMID: 29706566]

Interaction Information:

Comment FGF21 acts on adipocytes and renal cells to promote induction of angiotensin-converting enzyme 2 (ACE2), which in turn converts angiotensin II to angiotensin-(1-7), then inhibits hypertension and reverses vascular damage.
Formal Description
Interaction-ID: 117645



increases_quantity of


Angiotensin (1-7)

in adipose tissue, in kidney; via ACE2