General Information:

Id: 11,936 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Mus musculus
article
Reference: Santos RA et al.(2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas Proc. Natl. Acad. Sci. U.S.A. 100: 8258-8263 [PMID: 12829792]

Interaction Information:

Comment The study demonstrates that genetic deletion of the G protein-coupled receptor encoded by the Mas protooncogene abolishes the binding of Ang-(1-7) to mouse kidneys. Mas-deficient mice completely lack the antidiuretic action of Ang-(1-7) after an acute water load. Ang-(1-7) binds to Mas-transfected cells and elicits arachidonic acid release.
Formal Description
Interaction-ID: 117318

gene/protein

Angiotensin (1-7)

increases_activity of

gene/protein

MAS1

in kidney