General Information:

Id: 11,933 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Homo sapiens
article
Reference: Bosnyak S et al.(2011) Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors Clin. Sci. 121: 297-303 [PMID: 21542804]

Interaction Information:

Comment In the AT2R-transfected HEK-293 cells, competition for 125I-[Sar1Ile8]AngII binding was observed for all ligands except candesartan, AVE0991 and A-779, the latter two compounds having negligible affinity at either AT1R or AT2R. The rank order of affinity of ligands at AT2R was CGP42112>AngII>AngIII>Compound 21>PD123319AngIV [angiotensin IV; angiotensin-(3-8)]>Ang-(1-7) [angiotensin-(1-7)]. Of note, although AngIV and Ang-(1-7) exhibited only modest affinity at AT2R compared with AngII, these two angiotensin peptides, together with AngIII, had substantial AT2R selectivity over AT1R. Collectively, our results suggest that shorter angiotensin peptides can act as endogenous ligands at AT2R.
Formal Description
Interaction-ID: 117315

gene/protein

Angiotensin (1-7)

interacts (colocalizes) with

gene/protein

AGTR2

in HEK293 cells
Drugbank entries Show/Hide entries for AGTR2