General Information:

Id: 11,928
Diseases: Cardiovascular disease
Homo sapiens
article
Reference: Tetzner A et al.(2016) G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A Hypertension 68: 185-194 [PMID: 27217404]

Interaction Information:

Comment Angiotensin (Ang)-(1-7) has cardiovascular protective effects and is the opponent of the often detrimental Ang II within the renin-angiotensin system. The study aimed to identify a second messenger stimulated by Ang-(1-7) allowing confirmation as well as discovery of the heptapeptide's receptors. Ang-(1-7) elevates cAMP concentration in primary cells, such as endothelial or mesangial cells. Using cAMP as readout in receptor-transfected human embryonic kidney (HEK293) cells, the study provided pharmacological proof that Mas is a functional receptor for Ang-(1-7). Moreover, the authors identified the G-protein-coupled receptor MrgD as a second receptor for Ang-(1-7).
Formal Description
Interaction-ID: 117302

gene/protein

Angiotensin (1-7)

increases_activity of

gene/protein

MAS1

in HEK293 cells
Comment Angiotensin (Ang)-(1-7) has cardiovascular protective effects and is the opponent of the often detrimental Ang II within the renin-angiotensin system. The study aimed to identify a second messenger stimulated by Ang-(1-7) allowing confirmation as well as discovery of the heptapeptide's receptors. Ang-(1-7) elevates cAMP concentration in primary cells, such as endothelial or mesangial cells. Using cAMP as readout in receptor-transfected human embryonic kidney (HEK293) cells, the study provided pharmacological proof that Mas is a functional receptor for Ang-(1-7). Moreover, the authors identified the G-protein-coupled receptor MrgD as a second receptor for Ang-(1-7).
Formal Description
Interaction-ID: 117307

gene/protein

Angiotensin (1-7)

increases_activity of

gene/protein

MRGPRD

in HEK293 cells
Comment Stimulation of HUVEC with Ang-(1–7) for 15 minutes resulted in a significant increase in PKA activity.
Formal Description
Interaction-ID: 117308

gene/protein

Angiotensin (1-7)

increases_activity of

complex/PPI

Protein kinase A

in HUVECs