General Information:

Id: 11,922 (click here to show other Interactions for entry)
Diseases: Lung disease
Mus musculus
Reference: de Carvalho Santuchi M et al.(2019) Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo Mediators Inflamm. 2019 [PMID: 30918468]

Interaction Information:

Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117272


Angiotensin (1-7)

decreases_expression of



in LPS plus IFNG-stimulated macrophages; via MAS1
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