General Information:

Id: 11,922
Diseases: Lung disease
Mus musculus
article
Reference: de Carvalho Santuchi M et al.(2019) Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo Mediators Inflamm. 2019 [PMID: 30918468]

Interaction Information:

Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117257

gene/protein

Angiotensin (1-7)

increases_activity of

gene/protein

MAS1

in LPS plus IFNG-stimulated macrophages
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117268

gene/protein

Alamandine

increases_activity of

gene/protein

MRGPRD

in LPS plus IFNG-stimulated macrophages
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117269

gene/protein

Alamandine

decreases_expression of

gene/protein

TNF

in LPS plus IFNG-stimulated macrophages; via MRGPRD
Drugbank entries Show/Hide entries for TNF
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117270

gene/protein

Angiotensin (1-7)

decreases_expression of

gene/protein

TNF

in LPS plus IFNG-stimulated macrophages; via MAS1
Drugbank entries Show/Hide entries for TNF
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117271

gene/protein

Alamandine

decreases_expression of

gene/protein

CCL2

in LPS plus IFNG-stimulated macrophages; via MRGPRD
Drugbank entries Show/Hide entries for CCL2
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117272

gene/protein

Angiotensin (1-7)

decreases_expression of

gene/protein

CCL2

in LPS plus IFNG-stimulated macrophages; via MAS1
Drugbank entries Show/Hide entries for CCL2
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117273

gene/protein

Alamandine

decreases_expression of

gene/protein

IL1B

in LPS plus IFNG-stimulated macrophages; via MRGPRD
Drugbank entries Show/Hide entries for IL1B
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117274

gene/protein

Angiotensin (1-7)

decreases_expression of

gene/protein

IL1B

in LPS plus IFNG-stimulated macrophages; via MAS1
Drugbank entries Show/Hide entries for IL1B
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117275

gene/protein

MAS1

decreases_expression of

gene/protein

IL1B

in LPS plus IFNG-stimulated macrophages
Drugbank entries Show/Hide entries for IL1B
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117276

gene/protein

MAS1

decreases_expression of

gene/protein

CCL2

in LPS plus IFNG-stimulated macrophages
Drugbank entries Show/Hide entries for CCL2
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117277

gene/protein

MAS1

decreases_expression of

gene/protein

TNF

in LPS plus IFNG-stimulated macrophages
Drugbank entries Show/Hide entries for TNF
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117278

gene/protein

MRGPRD

decreases_expression of

gene/protein

TNF

in LPS plus IFNG-stimulated macrophages
Drugbank entries Show/Hide entries for TNF
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117279

gene/protein

MRGPRD

decreases_expression of

gene/protein

CCL2

in LPS plus IFNG-stimulated macrophages
Drugbank entries Show/Hide entries for CCL2
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117280

gene/protein

MRGPRD

decreases_expression of

gene/protein

IL1B

in LPS plus IFNG-stimulated macrophages
Drugbank entries Show/Hide entries for IL1B
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117281

gene/protein

MRGPRD

decreases_activity of

in LPS plus IFNG-stimulated macrophages
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117282

gene/protein

MAS1

decreases_activity of

in LPS plus IFNG-stimulated macrophages
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117283

gene/protein

Angiotensin (1-7)

decreases_activity of

in LPS plus IFNG-stimulated macrophages; via MAS1
Comment The study evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the novel renin-angiotensin system (RAS) peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-gamma), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. The results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.
Formal Description
Interaction-ID: 117284

gene/protein

Alamandine

decreases_activity of

in LPS plus IFNG-stimulated macrophages; via MRGPRD