General Information:

Id: 11,908 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Rattus norvegicus
article
Reference: Walters PE et al.(2005) Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats Hypertension 45: 960-966 [PMID: 15767466]

Interaction Information:

Comment In the present study, Ang-(1–7) given acutely evoked only minimal effects on mean arterial pressure (MAP) and heart rate (HR). Conceivably, Ang-(1–7) could cause AT1R-mediated vasoconstriction and AT2R-mediated vasodilatation, which would then cancel each other out under basal conditions. Indeed, it was only when Ang-(1–7) and candesartan were coadministered, that a marked decrease in MAP in SHR and WKY rats was revealed.
Formal Description
Interaction-ID: 117217

drug/chemical compound

Candesartan

affects_activity of

gene/protein

Angiotensin (1-7)

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