General Information:

Id: 11,846 (click here to show other Interactions for entry)
Diseases: SARS-CoV infection
Homo sapiens
primary airway epithelia isolated from human donor trachea or bronchi; HEK293 cells; HeLa cells
Reference: Jia HP et al.(2009) Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia Am. J. Physiol. Lung Cell Mol. Physiol. 297: L84-L96 [PMID: 19411314]

Interaction Information:

Comment Additional data indicate that SARS-CoV S protein or SARS virus infection directly downregulates pulmonary ACE2 expression. (cited information)
Formal Description
Interaction-ID: 121119


SARS-CoV S protein

decreases_expression of



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