General Information:

Id: 11,846 (click here to show other Interactions for entry)
Diseases: SARS-CoV infection
Homo sapiens
primary airway epithelia isolated from human donor trachea or bronchi; HEK293 cells; HeLa cells
article/cited
Reference: Jia HP et al.(2009) Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia Am. J. Physiol. Lung Cell Mol. Physiol. 297: L84-L96 [PMID: 19411314]

Interaction Information:

Comment ACE2-RBD interacts with the SARS-CoV S protein. The SARS CoV spike receptor-binding domain is bound to ACE2.
Formal Description
Interaction-ID: 121044

gene/protein

ACE2

interacts (colocalizes) with

environment

SARS-CoV S protein

Drugbank entries Show/Hide entries for ACE2
Comment ACE2 is shed from human airway epithelia, a site of SARS-CoV infection.
Formal Description
Interaction-ID: 121117

gene/protein

ACE2

increases_activity of

disease

SARS-CoV infection

Drugbank entries Show/Hide entries for ACE2
Comment Additional data indicate that SARS-CoV S protein or SARS virus infection directly downregulates pulmonary ACE2 expression. (cited information)
Formal Description
Interaction-ID: 121118

disease

SARS-CoV infection

decreases_expression of

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2
Comment Additional data indicate that SARS-CoV S protein or SARS virus infection directly downregulates pulmonary ACE2 expression. (cited information)
Formal Description
Interaction-ID: 121119

environment

SARS-CoV S protein

decreases_expression of

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2