General Information:

Id: 11,841 (click here to show other Interactions for entry)
Diseases: COVID-19
SARS-CoV infection
Mammalia
review
Reference: Gheblawi M et al.Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System [PMID: 32264791]

Interaction Information:

Comment The entry of both SARS-CoV and SARS-CoV-2 into cells is facilitated by the interaction between viral S-protein with extracellular domains of the transmembrane ACE2 proteins, followed by subsequent downregulation of surface ACE2 expression.
Formal Description
Interaction-ID: 116962

environment

SARS-CoV S protein

decreases_expression of

gene/protein

ACE2

concerning downregulation of surface ACE2 expression
Drugbank entries Show/Hide entries for ACE2