General Information:

Id: 11,841 (click here to show other Interactions for entry)
Diseases: COVID-19
SARS-CoV infection
Mammalia
review
Reference: Gheblawi M et al.Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System [PMID: 32264791]

Interaction Information:

Comment ADAM17 (a disintegrin and metalloproteinase 17)-mediated proteolytic cleavage of ACE2 is upregulated by endocytosed SARS-CoV-2 spike proteins.
Formal Description
Interaction-ID: 116918

gene/protein

ADAM17

increases_processing of

gene/protein

ACE2

via proteolytic cleavage
Drugbank entries Show/Hide entries for ADAM17 or ACE2