General Information:

Id: 11,830 (click here to show other Interactions for entry)
Diseases: SARS-CoV infection
Mus musculus
article
Reference: Kuba K et al.(2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Nat. Med. 11: 875-879 [PMID: 16007097]

Interaction Information:

Comment During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world. A new coronavirus (SARS-CoV) was identified as the SARS pathogen, which triggered severe pneumonia and acute, often lethal, lung failure. The study provides genetic proof that ACE2 is a crucial SARS-CoV receptor in vivo.
Formal Description
Interaction-ID: 116827

environment

SARS-CoV

interacts (colocalizes) with

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2
Comment SARS-CoV infections and the Spike protein of the SARS-CoV reduce ACE2 expression.
Formal Description
Interaction-ID: 116880

disease

SARS-CoV infection

decreases_expression of

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2
Comment SARS-CoV Spike protein binding to ACE2 in cell lines or SARS-CoV infections in vivo results in reduced ACE2 protein expression.
Formal Description
Interaction-ID: 116881

environment

SARS-CoV S protein

decreases_expression of

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2
Comment Decreased ACE2 protein, but normal ACE levels, were found in the lungs of SARS-CoV–infected mice.
Formal Description
Interaction-ID: 119082

disease

SARS-CoV infection

decreases_quantity of

gene/protein

ACE2

in the lung
Drugbank entries Show/Hide entries for ACE2