General Information:

Id: 11,829
Diseases: SARS-CoV infection
Homo sapiens
article
Reference: Li W et al.(2003) Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Nature 426: 450-454 [PMID: 14647384]

Interaction Information:

Comment Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target cells. The authors identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2), isolated from SARS coronavirus (SARS-CoV)-permissive Vero E6 cells, that efficiently binds the S1 domain of the SARS-CoV S protein. A soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells. SARS-CoV replicated efficiently on ACE2-transfected but not mock-transfected 293T cells. Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together the data indicate that ACE2 is a functional receptor for SARS-CoV.
Formal Description
Interaction-ID: 116826

environment

SARS-CoV S protein

interacts (colocalizes) with

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2