General Information:

Id: 11,826 (click here to show other Interactions for entry)
Diseases: COVID-19
Homo sapiens
Reference: Zhou P et al.(2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin Nature 579: 270-273 [PMID: 32015507]

Interaction Information:

Comment ACE2 is known to be a cell receptor for SARS-CoV. To determine whether 2019-nCoV also uses ACE2 as a cellular entry receptor, the authors conducted virus infectivity studies using HeLa cells that expressed or did not express ACE2 proteins from humans, Chinese horseshoe bats, civets, pigs and mice. 2019-nCoV is able to use all ACE2 proteins, except for mouse ACE2, as an entry receptor to enter ACE2-expressing cells, but not cells that did not express ACE2, indicating that ACE2 is probably the cell receptor through which 2019-nCoV enters cells.
Formal Description
Interaction-ID: 116858



interacts (colocalizes) with



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