General Information:

Id: 11,823 (click here to show other Interactions for entry)
Diseases: Metabolic
Homo sapiens
article
Reference: Vickers C et al.(2002) Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase J Biol Chem 277 [PMID: 11815627]

Interaction Information:

Comment Dynorphin A 1-13, identified as a good ACE2 substrate in vitro, is an endogenous opioid neuropeptide with antinociceptive effects. Dynorphin 1-13 is hydrolyzed by ACE2 to Dynorphin 1-12, which possesses 50- to 230-fold weaker binding affinity to the kappa-opioid receptor than does dynorphin A 1–13.
Formal Description
Interaction-ID: 116846

gene/protein

ACE2

decreases_quantity of

gene/protein

Dynorphin A (1-13)

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