General Information:

Id: 11,823 (click here to show other Interactions for entry)
Diseases: Metabolic
Homo sapiens
article
Reference: Vickers C et al.(2002) Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase J Biol Chem 277 [PMID: 11815627]

Interaction Information:

Comment ACE2 activity is increased by about 10-fold by Cl- and F- but is unaffected by Br-.
Formal Description
Interaction-ID: 116801

drug/chemical compound

Cl-

increases_activity of

gene/protein

ACE2

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Comment ACE2 activity is increased by about 10-fold by Cl- and F- but is unaffected by Br-.
Formal Description
Interaction-ID: 116803

drug/chemical compound

Fluoride

increases_activity of

gene/protein

ACE2

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Comment Purified human ACE2 hydrolyzes Ang II with high catalytic efficiency to produce angiotensin (1-7). The catalytic efficiency of ACE2 is 400 times higher on angiotensin II than on angiotensin I. The other peptides, angiotensin 1-9, angiotensin 1-7, and angiotensin 1-5, are poorly hydrolyzed or not hydrolyzed at all by ACE2.
Formal Description
Interaction-ID: 116804

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin II

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Comment Purified human ACE2 hydrolyzes Ang II with high catalytic efficiency to produce angiotensin (1-7). The catalytic efficiency of ACE2 is 400 times higher on angiotensin II than on angiotensin I. The other peptides, angiotensin 1-9, angiotensin 1-7, and angiotensin 1-5, are poorly hydrolyzed or not hydrolyzed at all by ACE2.
Formal Description
Interaction-ID: 116809

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-7)

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Comment ACE2 hydrolyzes in vitro the hormone apelin-13 with high catalytic efficiency and cleaves apelin-36. Apelin-13 and apelin-36 are ligands for the human APJ receptor.
Formal Description
Interaction-ID: 116812

gene/protein

ACE2

decreases_quantity of

gene/protein

Apelin-13

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Comment ACE2 hydrolyzes in vitro the hormone apelin-13 with high catalytic efficiency and cleaves apelin-36. Apelin-13 and apelin-36 are ligands for the human APJ receptor.
Formal Description
Interaction-ID: 116814

gene/protein

ACE2

decreases_quantity of

gene/protein

Apelin-36

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Comment Dynorphin A 1-13, identified as a good ACE2 substrate in vitro, is an endogenous opioid neuropeptide with antinociceptive effects. Dynorphin 1-13 is hydrolyzed by ACE2 to Dynorphin 1-12, which possesses 50- to 230-fold weaker binding affinity to the kappa-opioid receptor than does dynorphin A 1–13.
Formal Description
Interaction-ID: 116846

gene/protein

ACE2

decreases_quantity of

gene/protein

Dynorphin A (1-13)

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Comment Dynorphin A 1-13, identified as a good ACE2 substrate in vitro, is an endogenous opioid neuropeptide with antinociceptive effects. Dynorphin 1-13 is hydrolyzed by ACE2 to Dynorphin 1-12, which possesses 50- to 230-fold weaker binding affinity to the kappa-opioid receptor than does dynorphin A 1–13.
Formal Description
Interaction-ID: 116849

gene/protein

ACE2

increases_quantity of

gene/protein

Dynorphin A (1-12)

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Comment ACE2 hydrolyzes des-Arg9-bradykinin in vitro.
Formal Description
Interaction-ID: 116852

gene/protein

ACE2

decreases_quantity of

gene/protein

des-Arg9-bradykinin

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Comment Neurotensin 1-8 is a fragment of the active form of the neuropeptide and is itself not known to be biologically active.
Formal Description
Interaction-ID: 116855

gene/protein

ACE2

decreases_quantity of

gene/protein

Neurotensin 1-8

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Comment Purified human ACE2 hydrolyzes Ang II with high catalytic efficiency to produce angiotensin (1-7). The catalytic efficiency of ACE2 is 400 times higher on angiotensin II than on angiotensin I. The other peptides, angiotensin 1-9, angiotensin 1-7, and angiotensin 1-5, are poorly hydrolyzed or not hydrolyzed at all by ACE2.
Formal Description
Interaction-ID: 116859

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin I

with low activity as for angiotensin II
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