General Information:

Id: 11,821 (click here to show other Interactions for entry)
Diseases: COVID-19
Mammalia
review
Reference: Kai H and Kai MInteractions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors-lessons from available evidence and insights into COVID-19 [PMID: 32341442]

Interaction Information:

Comment Human ACE2 is an established functional receptor by which SARS-CoV enters host target cells. The transmembrane spike glycoprotein (S protein) of SARS-CoV binds to the cellular membrane ACE2; SARS-CoV then attaches to the target cells, followed by SARS-CoV-S protein priming by cellular surface proteases, such as transmembrane protease serine 2 (TMPRSS2), allowing the fusion of viral and cellular membranes and resulting in SARS-CoV entry and replication in the target cell.
Formal Description
Interaction-ID: 116761

environment

SARS-CoV S protein

interacts (colocalizes) with

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2