General Information:

Id: 11,778 (click here to show other Interactions for entry)
Diseases: COVID-19
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Hussain A et al.(2020) COVID-19 and diabetes: Knowledge in progress Diabetes Res. Clin. Pract. 162 [PMID: 32278764]

Interaction Information:

Comment Viral entry into the host cells is a fundamental componen tof cross-species transmission, particularly for the coronaviruses (CoVs). Upon exposure of the host to the virus, all CoVs, through a Spike protein, bind to cells that express specific receptors. After binding to the target cells, the host-cell protease cleaves the spike, which allows the virus to enter and replicate. The angiotensin-converting enzyme 2 (ACE2) has been identified as one of the main receptors for both SARS-CoV and SARS-CoV-2.
Formal Description
Interaction-ID: 116650

environment

SARS-CoV S protein

interacts (colocalizes) with

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2