General Information:

Id: 11,776 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Bader M(2013) ACE2, angiotensin-(1-7), and Mas: the other side of the coin Pflugers Arch. 465: 79-85 [PMID: 23463883]

Interaction Information:

Comment Mas deficiency in mice induces a metabolic syndrome-like state, with dyslipidemia, lower glucose tolerance and insulin sensitivity, hyperinsulinemia, decreased glucose uptake in white adipose cells, and an increase in adipose tissue mass. In accordance, chronically increased Ang-(1–7) levels in transgenic rats reduce the amount of fat tissue and plasma lipid levels and enhance glucose tolerance and insulin sensitivity.
Formal Description
Interaction-ID: 116625


Angiotensin (1-7)

decreases_activity of


Insulin resistance