General Information:

Id: 11,776 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Bader M(2013) ACE2, angiotensin-(1-7), and Mas: the other side of the coin Pflugers Arch. 465: 79-85 [PMID: 23463883]

Interaction Information:

Comment Besides NO-releasing, antioxidative, NO-increasing, and direct anti-hypertrophic effects on cardiomyocytes, the main actions of Ang-(1–7) in the heart seem to be the regulation of genes involved in fibrosis in cardiac fibroblasts via Mas. Accordingly, Mas agonists attenuate heart failure after myocardial infarction.
Formal Description
Interaction-ID: 116614

gene/protein

Angiotensin (1-7)

affects_activity of

phenotype

cardiac fibrosis