General Information:

Id: 11,776 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Bader M(2013) ACE2, angiotensin-(1-7), and Mas: the other side of the coin Pflugers Arch. 465: 79-85 [PMID: 23463883]

Interaction Information:

Comment Diabetic cardiomyopathy is exacerbated in the absence of ACE2, again based on increased oxidative stress. In the opposite, local overexpression of ACE2 in the heart by lentiviral gene transfer elicited cardioprotective actions in several disease models.
Formal Description
Interaction-ID: 116613

gene/protein

ACE2

affects_activity of

disease

Cardiomyopathy, diabetic

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