General Information:

Id: 11,776 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Bader M(2013) ACE2, angiotensin-(1-7), and Mas: the other side of the coin Pflugers Arch. 465: 79-85 [PMID: 23463883]

Interaction Information:

Comment Ang II-induced kidney damage and diabetic nephropathy are aggravated in ACE2-deficient mice, and the Ang II effects are ameliorated by recombinant ACE2 in wild-type animals. Ang-(1–7) infusion reverts diabetic renal damage in mice and rats, and Mas agonists protect the kidney from ischemia/reperfusion damage. The mechanism involved in most of these cases seems to be a reductionin oxidative stress and reduced fibrosis by the components of the ACE2/Ang-(1–7)/Mas axis.
Formal Description
Interaction-ID: 116610


Angiotensin (1-7)

decreases_activity of


Nephropathy, diabetic