General Information:

Id: 11,776 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Bader M(2013) ACE2, angiotensin-(1-7), and Mas: the other side of the coin Pflugers Arch. 465: 79-85 [PMID: 23463883]

Interaction Information:

Comment In atherosclerosis, the ACE2/Ang-(1–7)/Mas axis was shown to be protective. The genetic ablation of ACE2 significantly increases, and transgenic vascular ACE2 over-expression decreases plaque formation in atherosclerotic apolipoprotein E or LDL receptor-deficient mice. In one study, the transfer of ACE2-deficient bone marrow into LDL receptor-deficient mice was already sufficient to aggravate plaque formation indicating that the enzyme on leukocytes is particularly beneficial in the atherosclerotic process. Moreover, long-term Ang-(1–7) treatment induces protective effects in such animals. In these cases again, an improvement of the redox balance by Ang-(1–7) has been reported to be pivotal for the anti-atherogenic effect.
Formal Description
Interaction-ID: 116606


Angiotensin (1-7)

decreases_activity of