General Information:

Id: 11,776 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Bader M(2013) ACE2, angiotensin-(1-7), and Mas: the other side of the coin Pflugers Arch. 465: 79-85 [PMID: 23463883]

Interaction Information:

Comment Ang-(1–7) triggers NO release by Akt phosphorylation inducing the activation of endothelial NO synthase and inhibits Ang II-induced reactive oxygen species (ROS) production in endothelial cells. Accordingly, vessels of Mas-deficient mice produce more ROS and less NO leading to an impaired in vivo endothelial function and increased blood pressure. In the opposite, an improved endothelial function was observed in stroke-prone spontaneously hypertensive rats (SHRSP) expressing a human ACE2 transgene in vascular smooth muscle cells.
Formal Description
Interaction-ID: 116604


Angiotensin (1-7)

decreases_quantity of

drug/chemical compound

Reactive oxygen species

in vascular endothelial cells