General Information:

Id: 11,776 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Bader M(2013) ACE2, angiotensin-(1-7), and Mas: the other side of the coin Pflugers Arch. 465: 79-85 [PMID: 23463883]

Interaction Information:

Comment Angiotensin peptides are metabolized by several subsequent enzymatic steps: First, renin cleaves angiotensinogen, into angiotensin I (Ang I). Ang I can be metabolized by angiotensin-converting enzyme (ACE) resulting in the production of the bioactive octapeptide angiotensin II (Ang II), which interacts with AT1 and AT2 receptors. Alternatively, it can be processed first by ACE2 to the inactive peptide Ang-(1–9) and then by ACE to Ang-(1–7) or by neutral endopeptidase 24.11 (NEP) or prolylendopeptidase (PEP) directly to Ang-(1–7). Ang-(1–7) can also be generated by ACE2 from Ang II and interacts with its receptor Mas.
Formal Description
Interaction-ID: 116580

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin I

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Comment Angiotensin peptides are metabolized by several subsequent enzymatic steps: First, renin cleaves angiotensinogen, into angiotensin I (Ang I). Ang I can be metabolized by angiotensin-converting enzyme (ACE) resulting in the production of the bioactive octapeptide angiotensin II (Ang II), which interacts with AT1 and AT2 receptors. Alternatively, it can be processed first by ACE2 to the inactive peptide Ang-(1–9) and then by ACE to Ang-(1–7) or by neutral endopeptidase 24.11 (NEP) or prolylendopeptidase (PEP) directly to Ang-(1–7). Ang-(1–7) can also be generated by ACE2 from Ang II and interacts with its receptor Mas.
Formal Description
Interaction-ID: 116581

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-9)

Drugbank entries Show/Hide entries for ACE2
Comment Angiotensin peptides are metabolized by several subsequent enzymatic steps: First, renin cleaves angiotensinogen, into angiotensin I (Ang I). Ang I can be metabolized by angiotensin-converting enzyme (ACE) resulting in the production of the bioactive octapeptide angiotensin II (Ang II), which interacts with AT1 and AT2 receptors. Alternatively, it can be processed first by ACE2 to the inactive peptide Ang-(1–9) and then by ACE to Ang-(1–7) or by neutral endopeptidase 24.11 (NEP) or prolylendopeptidase (PEP) directly to Ang-(1–7). Ang-(1–7) can also be generated by ACE2 from Ang II and interacts with its receptor Mas.
Formal Description
Interaction-ID: 116588

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin II

Drugbank entries Show/Hide entries for ACE2
Comment Angiotensin peptides are metabolized by several subsequent enzymatic steps: First, renin cleaves angiotensinogen, into angiotensin I (Ang I). Ang I can be metabolized by angiotensin-converting enzyme (ACE) resulting in the production of the bioactive octapeptide angiotensin II (Ang II), which interacts with AT1 and AT2 receptors. Alternatively, it can be processed first by ACE2 to the inactive peptide Ang-(1–9) and then by ACE to Ang-(1–7) or by neutral endopeptidase 24.11 (NEP) or prolylendopeptidase (PEP) directly to Ang-(1–7). Ang-(1–7) can also be generated by ACE2 from Ang II and interacts with its receptor Mas.
Formal Description
Interaction-ID: 116589

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-7)

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Comment Ang II-induced kidney damage and diabetic nephropathy are aggravated in ACE2-deficient mice, and the Ang II effects are ameliorated by recombinant ACE2 in wild-type animals. Ang-(1–7) infusion reverts diabetic renal damage in mice and rats, and Mas agonists protect the kidney from ischemia/reperfusion damage. The mechanism involved in most of these cases seems to be a reductionin oxidative stress and reduced fibrosis by the components of the ACE2/Ang-(1–7)/Mas axis.
Formal Description
Interaction-ID: 116609

gene/protein

ACE2

decreases_activity of

disease

Nephropathy, diabetic

Drugbank entries Show/Hide entries for ACE2
Comment Diabetic cardiomyopathy is exacerbated in the absence of ACE2, again based on increased oxidative stress. In the opposite, local overexpression of ACE2 in the heart by lentiviral gene transfer elicited cardioprotective actions in several disease models.
Formal Description
Interaction-ID: 116613

gene/protein

ACE2

affects_activity of

disease

Cardiomyopathy, diabetic

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Comment ACE2 is involved in the regulation of insulin secretion in the pancreas.
Formal Description
Interaction-ID: 116626

gene/protein

ACE2

affects_activity of

in pancreas
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