General Information:

Id: 11,758 (click here to show other Interactions for entry)
Diseases: Pulmonary fibrosis, idiopathic - [OMIM]
Homo sapiens
Reference: Shao M et al.(2019) Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-beta1 in alveolar epithelial cells Biomed. Pharmacother. 117 [PMID: 31387171]

Interaction Information:

Comment Ang-(1-7) inhibits TGF-beta1-induced phosphorylation of Smad2 and Smad3, and suppressed the expression of the downstream target gene of TGF-beta1-SMAD signaling, including ZEB1, ZEB2, TWIST, and SNAIL1.
Formal Description
Interaction-ID: 116455


Angiotensin (1-7)

decreases_expression of



in A549 cells; via inhibition of TGFbeta1-SMAD signaling